Area of research
Pulmonary and Respiratory Medicine · Molecular Biology
Research interest
Research interests include PI3K/AKT/mTOR signaling in cancer, Advanced Breast Cancer Therapies, Cancer Genomics and Diagnostics, and Chronic Lymphocytic Leukemia Research.
The intrinsic substrate specificity of the human tyrosine kinome
An atlas of substrate specificities for the human serine/threonine kinome
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity
Data from Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple <i>PIK3CA</i> Mutations
At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy
Dietary fructose improves intestinal cell survival and nutrient absorption
Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis
Alterations in PTEN and ESR1 promote clinical resistance to alpelisib plus aromatase inhibitors
TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors
Phase and context shape the function of composite oncogenic mutations
A view on drug resistance in cancer
Double <i>PIK3CA</i> mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
A RAS Renaissance: Emerging Targeted Therapies for KRAS-Mutated Non–Small Cell Lung Cancer