Area of research
Infectious Diseases · Computational Theory and Mathematics
Research interest
Research interests include SARS-CoV-2 and COVID-19 Research, Computational Drug Discovery Methods, Viral Infections and Immunology Research, and Viral gastroenteritis research and epidemiology.
Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir
A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations
Structure-based design of SARS-CoV-2 papain-like protease inhibitors
Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor
Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity
Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays
Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with <i>in vivo</i> antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses