Area of research
Physiology · Pharmacology
Research interest
Research interests include Alzheimer's disease research and treatments, Cholinesterase and Neurodegenerative Diseases, Prion Diseases and Protein Misfolding, and Drug Transport and Resistance Mechanisms.
Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment
Localized APP expression results in progressive network dysfunction by disorganizing spike timing
Localized APP pathology in the hippocampus is sufficient to result in progressive disorganization of the timing of neuronal firing patterns
World‐Wide FINGERS Network: A global approach to risk reduction and prevention of dementia
Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s Disease
The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy
Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke
Tauopathy-Associated PERK Alleles are Functional Hypomorphs that Increase Neuronal Vulnerability to ER Stress
Short Aβ peptides attenuate Aβ42 toxicity in vivo
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission
Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology
Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA
Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway
The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes
Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1–Induced Pluripotent Stem Cell Mutant Carriers
Emerging Therapeutics for Alzheimer's Disease
γ-Secretase inhibitors and modulators
Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway
Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice
Prevalence of cognitive impairment in Chinese: Epidemiology of Dementia in Singapore study
Steroids as γ‐secretase modulators
Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
Amyloid precursor protein (APP) regulates synaptic structure and function
Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration