Area of research
Physiology · Computational Theory and Mathematics
Research interest
Research focused on Proteases and Discontinuation, with related work in Neuroscience, Mechanism (biology), Amyloid precursor protein. Notable publications include 'γ-Secretase inhibitors and modulators', 'Cyanobacterial Peptides as a Prototype for the Design of Potent β-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases', and 'Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology'.
γ-Secretase inhibitors and modulators
Steroids as γ‐secretase modulators
Cyanobacterial Peptides as a Prototype for the Design of Potent β-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases
Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology