Area of research
Molecular Biology · Neurology
Research interest
Research interests include RNA Research and Splicing, Amyotrophic Lateral Sclerosis Research, Heat shock proteins research, and Prion Diseases and Protein Misfolding.
Phase Separation in Biology and Disease; Current Perspectives and Open Questions
Tuning Hsp104 specificity to selectively detoxify α-synuclein
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
AAA+ proteins: one motor, multiple ways to work
Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology
Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS
Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis
Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers
Therapeutic genetic variation revealed in diverse Hsp104 homologs
Tuning Hsp104 specificity to selectively detoxify α-synuclein
Therapeutic genetic variation revealed in diverse Hsp104 homologs
Author response: Therapeutic genetic variation revealed in diverse Hsp104 homologs
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43
Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death
Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations
CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation
Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase
Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases
The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate
Protein Phase Separation: A New Phase in Cell Biology
The molecular language of membraneless organelles
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity
FUS Regulates Activity of MicroRNA-Mediated Gene Silencing
Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events
Neurodegenerative disease: models, mechanisms, and a new hope
Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures