Area of research
Neurology · Genetics
Research interest
Research interests include Amyotrophic Lateral Sclerosis Research, Neurogenetic and Muscular Disorders Research, Genetic Neurodegenerative Diseases, and RNA Research and Splicing.
A molecular atlas of adult C. elegans motor neurons reveals ancient diversity delineated by conserved transcription factor codes
Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes
Challenges of profiling motor neuron transcriptomes from human spinal cord
FTLD targets brain regions expressing recently evolved genes
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems
The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems. Source data
The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems. Source data
Neurotoxic reactive astrocytes induce cell death via saturated lipids
A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation
p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
<i>C9orf72</i> -derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility
Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain
Evolution of a Human-Specific Tandem Repeat Associated with ALS
Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties
Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
Stress Granule Assembly Disrupts Nucleocytoplasmic Transport
CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity
Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene
Neurodegenerative disease: models, mechanisms, and a new hope
Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress
Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
ATXN2 trinucleotide repeat length correlates with risk of ALS
Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
Innovating next generation technologies to define mechanisms of neurodegenerative disease and devise therapeutic strategies
Innovating next generation technologies to define mechanisms of neurodegenerative disease and devise therapeutic strategies
Discovery of novel TDP-43 splicing targets: the Achilles heel for FTD and towards sensitive biomarkers and therapeutic targets
Discovery of novel TDP-43 splicing targets: the Achilles heel for FTD and towards sensitive biomarkers and therapeutic targets
Discovery of novel TDP-43 splicing targets: the Achilles heel for FTD and towards sensitive biomarkers and therapeutic targets
2020 Molecular & Cellular Neurobiology Gordon Research Conference and Gordon Research Seminar
Innovating high-resolution novel imaging approaches to elucidate mechanisms of prion-like spreading of neurodegenerative disease
Innovating high-resolution novel imaging approaches to elucidate mechanisms of prion-like spreadingof neurodegenerative disease
Innovating high-resolution novel imaging approaches to elucidate mechanisms of prion-like spreadingof neurodegenerative disease
Innovating high-resolution novel imaging approaches to elucidate mechanisms of prion-like spreadingof neurodegenerative disease
Innovating high-resolution novel imaging approaches to elucidate mechanisms of prion-like spreadingof neurodegenerative disease
Defining modifiers and mechanisms of RAN translation
Innovating high-resolution novel imaging approaches to elucidate mechanisms of prion-like spreading of neurodegenerative disease
Defining modifiers and mechanisms of RAN translation
Defining modifiers and mechanisms of RAN translation
Defining modifiers and mechanisms of RAN translation
Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease
Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease
Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease
Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease
Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease
Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease