Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research focused on G protein-coupled receptor and Virtual screening, with related work in Receptor, Opioid, Morphine. Notable publications include 'Structure-based discovery of opioid analgesics with reduced side effects', 'Structure-based discovery of nonopioid analgesics acting through the α 2A -adrenergic receptor', and 'Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR'.
Structure and dynamics determine G protein coupling specificity at a class A GPCR
99mTc-Labeled Diarylpyrazoles for Single-Emission Computer Tomography Imaging of Neurotensin Receptor-Positive Tumors: A Comparative Preclinical Study
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β <sub>2</sub> ‐Adrenoceptor
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β <sub>2</sub> ‐Adrenoceptor
A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR
Dually Labeled Neurotensin NTS<sub>1</sub>R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays
Covalent and Visible‐Light Photoswitchable Derivatives of the Potent Synthetic Opioid Isotonitazene and Other Nitazenes
Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands
Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14
Development of Photoswitchable Tethered Ligands that Target the μ‐Opioid Receptor
Structure-based discovery of nonopioid analgesics acting through the α <sub>2A</sub> -adrenergic receptor
Structure‐Based Evolution of G Protein‐Biased μ‐Opioid Receptor Agonists
Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation
Synthesis, Characterization, and Application of Muscarinergic M<sub>3</sub> Receptor Ligands Linked to Fluorescent Dyes
Abolishing Dopamine D<sub>2long</sub>/D<sub>3</sub> Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H<sub>2</sub> Receptor Agonists
Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor
Structure-based development of caged dopamine D2/D3 receptor antagonists
Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M<sub>2</sub> Receptor
Fluorescence Labeling of Neurotensin(8–13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity
Conjugation of Short Peptides to Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Determines M<sub>2</sub>R Selectivity
Increasing the throughput of label-free cell assays to study the activation of G-protein-coupled receptors by using a serial agonist exposure protocol
Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Photochromic Dopamine Receptor Ligands Based on Dithienylethenes and Fulgides
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M<sub>2</sub> Muscarinic Acetylcholine Receptor
Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M<sub>2</sub>R Affinity and Selectivity
Structure-based discovery of opioid analgesics with reduced side effects
Mimicking of Arginine by Functionalized<i>N</i><sup>ω</sup>-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples
Dibenzo[ b , f ][1,4]oxazepines and dibenzo[ b , e ]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H 1 R, H 4 R, 5-HT 2A R and other selected GPCRs
NTS2-selective neurotensin mimetics with tetrahydrofuran amino acids