Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Receptor Mechanisms and Signaling, Neurotransmitter Receptor Influence on Behavior, Neuropeptides and Animal Physiology, and Protein Kinase Regulation and GTPase Signaling.
Structure and dynamics determine G protein coupling specificity at a class A GPCR
Mapping the conformational landscape of the stimulatory heterotrimeric G protein
Non-canonical β-adrenergic activation of ERK at endosomes
Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling
A photoswitchable GPCR-based opsin for presynaptic inhibition
Integrative RNA-omics Discovers <i>GNAS</i> Alternative Splicing as a Phenotypic Driver of Splicing Factor–Mutant Neoplasms
Leveraging nonstructural data to predict structures and affinities of protein–ligand complexes
Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane
Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor
Structure and selectivity engineering of the M <sub>1</sub> muscarinic receptor toxin complex
Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist
Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations
Rules of Engagement: GPCRs and G Proteins
Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Structure-based discovery of selective positive allosteric modulators of antagonists for the M <sub>2</sub> muscarinic acetylcholine receptor
Genetic evidence that β-arrestins are dispensable for the initiation of β <sub>2</sub> -adrenergic receptor signaling to ERK
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
Mechanistic insights into GPCR–G protein interactions
Structural basis for nucleotide exchange in heterotrimeric G proteins
Conformational biosensors reveal GPCR signalling from endosomes
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist