Area of research
Molecular Biology · Computational Theory and Mathematics
Research interest
Research interests include Melanoma and MAPK Pathways, Gene Regulatory Network Analysis, Bioinformatics and Genomic Networks, and Computational Drug Discovery Methods.
Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells
Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma
Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance
Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance
SPEED2: inferring upstream pathway activity from differential gene expression
SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells
Neuronal activity regulates alternative exon usage
Mutation-specific effects of NRAS oncogenes in colorectal cancer cells
Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe
An Integrative Genetic, Epigenetic and Proteomic Characterization of Pancreatic Neuroendocrine Neoplasms (PanNENs) defines Distinct Molecular Features of α- and β-cell like Subgroups
2020cited by 3position: middle
Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
Isoform-specific Ras signaling is growth factor dependent
The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs
Modelling signalling networks from perturbation data
Reverse engineering gene regulatory networks by modular response analysis – a benchmark
Comparative Network Reconstruction using mixed integer programming
Perturbation-response genes reveal signaling footprints in cancer gene expression
Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type–Specific Dynamic Logic Models
An immediate–late gene expression module decodes ERK signal duration
The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells
Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum
Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A
Consequences of feedback in signal transduction for targeted therapies
Computer-assisted curation of a human regulatory core network from the biological literature
Network quantification of EGFR signaling unveils potential for targeted combination therapy
Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS
Multilevel regulation of HIF-1 signaling by TTP