Area of research
Molecular Biology · Infectious Diseases
Research interest
Research interests include Wnt/β-catenin signaling in development and cancer, Cancer-related gene regulation, SARS-CoV-2 and COVID-19 Research, and Zeolite Catalysis and Synthesis.
Cryo-EM structures of light chain fibrils from abdominal fat biopsies of multiple myeloma patients.
Structure-based engineering of the midnolin-proteasome pathway for targeted protein degradation.
Rationally designed light-inducible RNA-releasing protein for translational regulation and optogenetic control of gene therapies
Design of Ig-like binders targeting α-synuclein fibril for mitigating its pathological activities.
CasRx-based Wnt activation promotes alveolar regeneration while ameliorating pulmonary fibrosis in a mouse model of lung injury.
EMDB—the Electron Microscopy Data Bank
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.
Announcing the launch of Protein Data Bank China as an Associate Member of the Worldwide Protein Data Bank Partnership.
Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome.
A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses, including all major Omicron strains.
Structure and function of extreme TLS DNA polymerase TTEDbh from Thermoanaerobacter tengcongensis.
Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from <i>Escherichia coli</i>.
Structural Basis of the Interaction between Human Axin2 and SIAH1 in the Wnt/β-Catenin Signaling Pathway.
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein.
Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity.
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.
Cryo-EM structure of human Wntless in complex with Wnt3a
Cryo-EM structure of human Wntless in complex with Wnt3a.
Potent neutralizing RBD-specific antibody cocktail against SARS-CoV-2 and its mutant.
Structural insights into SARS-CoV-2 infection and therapeutics development.
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Structure of M<sup>pro</sup> from SARS-CoV-2 and discovery of its inhibitors.
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Selective PP2A Enhancement through Biased Heterotrimer Stabilization.
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.
Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO.