Area of research
Immunology · Molecular Biology
Research interest
Research interests include Immune Cell Function and Interaction, T-cell and B-cell Immunology, Lipid Membrane Structure and Behavior, and Cellular transport and secretion.
Functional differences between rodent and human PD-1 linked to evolutionary divergence
Orientation-dependent CD45 inhibition with viral and engineered ligands
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity
CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity
CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis
<i>Cis</i> Interactions of Membrane Receptors and Ligands
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses
Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
TCR–pMHC bond conformation controls TCR ligand discrimination
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells
T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition
In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase
Phase separation of signaling molecules promotes T cell receptor signal transduction
A Structural Role for the Synaptobrevin 2 Transmembrane Domain in Dense-Core Vesicle Fusion Pores
In vitro membrane reconstitution of the T-cell receptor proximal signaling network
Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment