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Jason Moffat

Institute for Biomedical Engineering · CA
🔎 Find collaborators in Oncology · Molecular Biology →
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Area of research
Oncology · Molecular Biology
Research interest
Research interests include Peptidase Inhibition and Analysis, CRISPR and Genetic Engineering, Cancer Research and Treatments, and CAR-T cell therapy research.
h-index
74
citations
31,121
works
595
NIH funding
primary concept
Biology
email

Recent publications

The pathways for nanoparticle transport across tumour endothelium
Nature Nanotechnology 2025cited by 61position: middledoi
323 Development of nuclear envelope protein-targeting CAR T cells for treatment of hyperproliferative<i>MYC</i>-driven group 3 medulloblastoma
Regular and Young Investigator Award Abstracts 2024cited by 0position: middledoi
High-content CRISPR screening
Nature Reviews Methods Primers 2022cited by 564position: middledoi
High-content CRISPR screening
Nature Reviews Methods Primers 2022cited by 251position: middledoi
Context-dependent regulation of ferroptosis sensitivity
Cell chemical biology 2022cited by 113position: middledoi
A cohesin traffic pattern genetically linked to gene regulation
Nature Structural & Molecular Biology 2022cited by 86position: middledoi
NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
Science Advances 2021cited by 26position: middledoi
A Cohesin Traffic Pattern Genetically Linked to Gene Regulation
HAL (Le Centre pour la Communication Scientifique Directe) 2021cited by 20position: last
Cell cycle regulation of mitochondrial protein import revealed by genome-scale pooled bimolecular fluorescence complementation screening
bioRxiv (Cold Spring Harbor Laboratory) 2019cited by 1position: lastdoi
The shieldin complex mediates 53BP1-dependent DNA repair
Nature 2018cited by 648position: middledoi
Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
Nature Communications 2018cited by 55position: middledoi
Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies
Proceedings of the National Academy of Sciences 2018cited by 52position: middledoi
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
Cell 2016cited by 496position: middledoi
System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes
Molecular Cell 2016cited by 173position: middledoi
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
Cell 2015cited by 1,778position: lastdoi
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface
Cell 2015cited by 566position: middledoi
Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells
Cell Reports 2015cited by 206position: middledoi
A High Through-put Platform for Recombinant Antibodies to Folded Proteins
Molecular & Cellular Proteomics 2015cited by 117position: middledoi
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming
Nature 2013cited by 347position: middledoi
A Strategy for Modulation of Enzymes in the Ubiquitin System
Science 2013cited by 296position: middledoi
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities
Molecular Systems Biology 2013cited by 106position: lastdoi
Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation
Cell Reports 2012cited by 183position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Kevin R. Brown · Cancer Genetics (United States)3 papers (2015–2021)Katherine Chan · Hospital for Sick Children3 papers (2022–2025)Matthew A. Coelho · Wellcome Sanger Institute2 papers (2022–2022)Xiaowei Zhuang · Harvard University2 papers (2022–2022)Wei Li · University of Maryland, Baltimore2 papers (2022–2022)Tian Lu · Zhejiang University2 papers (2022–2022)Patricia Mero · University of Toronto2 papers (2015–2019)Lei S. Qi · Shanghai Jiao Tong University2 papers (2022–2022)Athma A. Pai · University of Massachusetts Chan Medical School2 papers (2021–2022)Geoff Stanley · Menlo School2 papers (2022–2022)Sergey V. Venev · Howard Hughes Medical Institute2 papers (2021–2022)Jonathan S. Weissman · Howard Hughes Medical Institute2 papers (2022–2022) · 2 papers (2022–2022)Florence M. Chardon · Seattle University2 papers (2022–2022)Job Dekker · Howard Hughes Medical Institute2 papers (2021–2022)Sachdev S. Sidhu · University of Waterloo2 papers (2015–2018)Keith A. Lawson · University Health Network2 papers (2022–2022)Christoph Bock · I.R.C.C.S. Oasi Maria SS2 papers (2022–2022)Benjamin G. Neel · NYU Langone Health2 papers (2012–2016)Anne-Laure Valton · Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement2 papers (2021–2022)
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