Area of research
Molecular Biology · Biophysics
Research interest
Research focused on DNA replication and Cell biology, with related work in RNA, RNA polymerase II, Cyclin-dependent kinase 7. Notable publications include 'Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors', 'CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer', and 'An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication'.
USP1-trapping lesions as a source of DNA replication stress and genomic instability
A two-step mechanism governing PARP1-DNA retention by PARP inhibitors
Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions
Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
A basal-level activity of ATR links replication fork surveillance and stress response
Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters
Super-resolution visualization of distinct stalled and broken replication fork structures
Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication
Disruption of Ca <sup>2+</sup> <sub>i</sub> Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2–Deficient Mice
XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery
Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks
PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading
Anosmin1 Shuttles Fgf to Facilitate Its Diffusion, Increase Its Local Concentration, and Induce Sensory Organs
A Method for Quantifying Molecular Interactions Using Stochastic Modelling and Super-Resolution Microscopy
Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry
ATR-Mediated Phosphorylation of FANCI Regulates Dormant Origin Firing in Response to Replication Stress
Dynamics of spontaneous flipping of a mismatched base in DNA duplex
Panorama of DNA hairpin folding observed<i>via</i>diffusion-decelerated fluorescence correlation spectroscopy