Area of research
Cardiology and Cardiovascular Medicine · Public Health, Environmental and Occupational Health
Research interest
Research focused on Sarcomere and Titin, with related work in Myosin, Cell biology, Actin. Notable publications include 'Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction', 'Novel insights into sarcomere regulatory systems control of cardiac thin filament activation', and 'Striated muscle proteins are regulated both by mechanical deformation and by chemical post-translational modification'.
Phenotype specific nuclear lamina remodeling in hiPSC derived cardiomyocytes bearing TNNT2 sarcomeric variants
Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy
Analysis of NIH K99/R00 awards and the career progression of awardees
P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function
Analysis of NIH K99/R00 Awards and the Career Progression of Awardees
The role of mechanosignaling in the control of myocardial mass
Cardiomyocyte external mechanical unloading activates modifications of α‐actinin differently from sarcomere‐originated unloading
Analysis of NIH K99/R00 awards and the career progression of awardees
Analysis of NIH K99/R00 Awards and the Career Progression of Awardees
Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy
Transthyretin deposition alters cardiomyocyte sarcomeric architecture, calcium transients, and contractile force
Novel insights into sarcomere regulatory systems control of cardiac thin filament activation
Striated muscle proteins are regulated both by mechanical deformation and by chemical post-translational modification
Mechanosignaling pathways alter muscle structure and function by post-translational modification of existing sarcomeric proteins to optimize energy usage
Eliminating the First Inactive State and Stabilizing the Active State of the Cardiac Regulatory System Alters Behavior in Solution and in Ordered Systems
CapZ integrates several signaling pathways in response to mechanical stiffness
Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction