Area of research
Epidemiology · Infectious Diseases
Research interest
Dr. Joshua Schiffer is an infectious disease physician and researcher who develops mathematical models to address significant medical challenges. A major focus of his work is to analyze strategies to achieve an HIV cure in people who require antiviral drugs for their entire lifetime, due to reservoirs of latent virus. These models assess the potential of a wide variety of potential curative technologies. Dr. Schiffer and colleagues also use mathematical modeling to study how T cells help control numerous herpes viruses that cause disease in healthy people and in cancer patients with compromised immune systems. They develop models to explain when and how latent viruses reactivate and use models to optimize the effectiveness of antiviral drugs. His team is also focusing on COVID-19, including developing models of the immune response against the coronavirus and the best treatment strategies.
Mild HIV-specific selective forces overlaying natural CD4+ T cell dynamics explain the clonality and decay dynamics of HIV reservoir cells
Impact of misclassified defective proviruses on HIV reservoir measurements
Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence
High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials
The STOP COVID 2 Study: Fluvoxamine vs Placebo for Outpatients With Symptomatic COVID-19, a Fully Remote Randomized Controlled Trial
Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients
Cytomegalovirus-specific T-cell reconstitution following letermovir prophylaxis after hematopoietic cell transplantation
Hydroxychloroquine with or without azithromycin for treatment of early SARS-CoV-2 infection among high-risk outpatient adults: A randomized clinical trial
Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART
Longitudinal study reveals HIV-1–infected CD4+ T cell dynamics during long-term antiretroviral therapy
A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation