Area of research
Physiology · Neurology
Research interest
Research interests include Alzheimer's disease research and treatments, Parkinson's Disease Mechanisms and Treatments, RNA Research and Splicing, and Neurotransmitter Receptor Influence on Behavior.
D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer’s disease
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils
Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient–extracted tau fibrils
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils
Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
De novo designed protein inhibitors of amyloid aggregation and seeding
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies