Area of research
Pulmonary and Respiratory Medicine · Complementary and alternative medicine
Research interest
Research topics from publications: Impact of Nrf2 Deficiency on Potassium Channel Function in Rat Soleus Arterioles; Role of Potassium Channel Function and Long‐term Exercise Training in Soleus Resistance Arterioles. Representative work: Introduction Nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) and its response element are essential in regulation of cellular oxidative stress. Nrf2 expression has also been linked to potassium (K + ) channel function. We hypothesized that vasoactive responses that are enhanced by exercise training and also modulated by K + channel function would be impaired in arterioles from skeletal muscle of rats in which Nrf2 (Nrf2 KO) is deleted. Methods Exercise training was performed in male wildtype (WT) Sprague‐Dawley rats, and their littermates lacking the Nrf2 gene (Nrf2 KO). Rats were exercise trained using a mixed moderate and high‐intensity interval treadmill program for 10‐12 weeks. After Introduction Nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) expression has been linked to potassium (K + ) channel function. We hypothesized that myogenic responses are enhanced by exercise training and also modulated by K + channel function but would be impaired in arterioles from skeletal muscle of trained rats in which Nrf2 (Nrf2 KO) is deleted. Methods Exercise training was performed in male wildtype (WT) Sprague‐Dawley rats, and their littermates lacking the Nrf2 gene (Nrf2 KO). Rats were exercise trained using a mixed moderate and high‐intensity interval treadmill program for 10‐12 weeks. A WT cage‐confined control group was also studied to compare the impact of exercise training.