Jacob T. Caldwell

Area of research

Complementary and alternative medicine · Cardiology and Cardiovascular Medicine

Research interest

Research topics from publications: Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin; Neurovascular dysfunction associated with erectile dysfunction persists after long‐term recovery from simulations of weightlessness and deep space irradiation; Preexercise intermittent passive stretching and vascular function after treadmill exercise; Adaptations of bone and bone vasculature to muscular stretch training; Effects of aging and exercise training on bone and marrow blood flow and vascular function; Impact of Nrf2‐deficiency on vasoreactivity of posterior cerebral arteries is sex‐specific; Static Muscle Stretching Enhances Vascular Responsiveness of the Tibial Nutrient Artery; Adiponectin‐deficient Mice Demonstrate Impaired Coronary Arteriolar Vasodilation and Subsequent Decline in Cardiac Function; Impact of Nrf2 Deficiency on Potassium Channel Function in Rat Soleus Arterioles; The Impact of Long‐Duration Exposure to Microgravity and Galactic Cosmic Radiation on Corpus Cavernosum Function. Representative work: We report that compensatory mechanisms contribute to the maintenance of cardiac and coronary microvascular function in sedentary mice in which adiponectin has been deleted; however, when mice lacking adiponectin are subjected to the physiological stress of exercise training, beneficial coronary microvascular and cardiac adaptations are compromised or absent There has been growing interest within the space industry for long-duration manned expeditions to the Moon and Mars. During deep space missions, astronauts are exposed to high levels of galactic cosmic radiation (GCR) and microgravity which are associated with increased risk of oxidative stress and endothelial dysfunction. Oxidative stress and endothelial dysfunction are causative factors in the pathogenesis of erectile dysfunction, although the effects of spaceflight on erectile function have been unexplored. Therefore, the purpose of this study was to investigate the effects of simulated spaceflight and long-term recovery on tissues critical for erectile function, the distal internal puden