Area of research
Physiology · Pharmacology
Research interest
Research interests include Alzheimer's disease research and treatments, Cholinesterase and Neurodegenerative Diseases, Parkinson's Disease Mechanisms and Treatments, and Prion Diseases and Protein Misfolding.
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease
Reducing the lipase LIPE in mutant α-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism
Aducanumab: Appropriate Use Recommendations Update
Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus
A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer’s brain
Parkinson’s disease: proteinopathy or lipidopathy?
Potential human transmission of amyloid β pathology: surveillance and risks
Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase
miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients
Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
Learnings about the complexity of extracellular tau aid development of a blood‐based screen for Alzheimer's disease
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability
Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory
The amyloid hypothesis of Alzheimer's disease at 25 years
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate
A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction
Preventing Alzheimer’s Disease
Plasma Amyloid-β as a Predictor of Dementia and Cognitive Decline
Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa