Area of research
Molecular Biology · Hematology
Research interest
Research focused on CEBPA and Chromatin, with related work in Atlas (anatomy), Enhancer, Cell biology. Notable publications include 'An atlas of active enhancers across human cell types and tissues', 'An integrated expression atlas of miRNAs and their promoters in human and mouse', and 'Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy'.
DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts
Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q
Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma
The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration
A microbial metabolite protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
The effector program of human CD8 T cells supports tissue remodeling
Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells
STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia
LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling
Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia
Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes
Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including <i>MNX1</i> activation via deletion 7q
Darwin’s “neuters” and the evolution of the sex continuum in a superorganism
S120: MNX1-ACTIVATING ENHANCER HIJACKING EVENTS IN ACUTE MYELOID LEUKEMIA WITH DELETIONS ON CHROMOSOME 7Q
Uterine enrichment of CD8+ T regulatory cells throughout pregnancy prevents fetal loss in mice
Biosensors for inflammation as a strategy to engineer regulatory T cells for cell therapy
Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation
Physiological levels of 25‐hydroxyvitamin D<sub>3</sub> induce a suppressive CD4<sup>+</sup> T cell phenotype not reflected in the epigenetic landscape
Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells
Allele-specific expression of <i>GATA2</i> due to epigenetic dysregulation in <i>CEBPA</i> double-mutant AML
Aberrant <scp>DNA</scp> methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the <scp>CpG</scp> island methylator phenotype
Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1
Temporal autoregulation during human PU.1 locus SubTAD formation
An integrated expression atlas of miRNAs and their promoters in human and mouse
In-vitro blockade of the CD4 receptor co-signal in antigen-specific T-cell stimulation cultures induces the outgrowth of potent CD4 independent T-cell effectors
An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation
An atlas of active enhancers across human cell types and tissues
5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes