Area of research
Molecular Biology · Hematology
Research interest
Research interests include Acute Myeloid Leukemia Research, Protein Degradation and Inhibitors, Epigenetics and DNA Methylation, and Cancer-related gene regulation.
MECOM is a master repressor of myeloid differentiation through dose control of <i>CEBPA</i> in acute myeloid leukemia
Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q
STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia
Oncogene <i>EVI1</i> drives acute myeloid leukemia via a targetable interaction with CTBP2
Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia
Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including <i>MNX1</i> activation via deletion 7q
Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsuficiency
<i>CEBPA</i> mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia
Allele-specific expression of <i>GATA2</i> due to epigenetic dysregulation in <i>CEBPA</i> double-mutant AML
Aberrant <scp>DNA</scp> methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the <scp>CpG</scp> island methylator phenotype