Area of research
Oncology · Biotechnology
Research interest
Research focused on Colorectal cancer and Organoid, with related work in Carcinogenesis, Stem cell, Progenitor cell. Notable publications include 'Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH', 'High-fat diet enhances stemness and tumorigenicity of intestinal progenitors', and 'WRN helicase is a synthetic lethal target in microsatellite unstable cancers'.
Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
Short-term post-fast refeeding enhances intestinal stemness via polyamines
Intestinal Cyp24a1 regulates vitamin D locally independent of systemic regulation by renal Cyp24a1 in mice
Colorectal Cancer Immunotherapy: State of the Art and Future Directions
Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in <i>KRAS</i> mutant colorectal cancer
Metabolism and Colorectal Cancer
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
High-fructose corn syrup enhances intestinal tumor growth in mice
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
Gut organoids: mini-tissues in culture to study intestinal physiology and disease
Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis
Colonoscopy-based colorectal cancer modeling in mice with CRISPR–Cas9 genome editing and organoid transplantation
Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications
Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Abstract B38: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Vitamin C selectively kills <i>KRAS</i> and <i>BRAF</i> mutant colorectal cancer cells by targeting GAPDH
Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of <i>BRAFV600E</i> Colorectal Cancer