Area of research
Immunology · Molecular Biology
Research interest
Research interests include Immune Cell Function and Interaction, Cell death mechanisms and regulation, interferon and immune responses, and Phagocytosis and Immune Regulation.
Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance.
TIM-3-dependent lysosome biogenesis is required for myelin debris clearance in macrophages.
hnRNPA2B1 induces HBV cccDNA degradation by recruiting APOBEC3B.
Xbp1 controls the reparative function of intestinal ILC2s during colitis.
Factors Associated With Early Reocclusion in Recanalized Intracranial Atherosclerotic Occlusion: ANGEL-REBOOT Insights
Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity
Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity.
Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8<sup>+</sup> T cell exhaustion and anti-PD-1 resistance.
Increased Siglec-9/Siglec-9L interactions on NK cells predict poor HCC prognosis and present a targetable checkpoint for immunotherapy
Urolithin A Hijacks ERK1/2-ULK1 Cascade to Improve CD8<sup>+</sup> T Cell Fitness for Antitumor Immunity.
Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus
Dynamic Hybrid Module-Driven NK Cell Stimulation and Release for Tumor Immunotherapy.
Sensing of Liver-Derived Nicotinamide by Intestinal Group 2 Innate Lymphoid Cells Links Liver Cirrhosis and Ulcerative Colitis Susceptibility.
TIPE1 limits virus replication by disrupting PKM2/ HIF-1α/ glycolysis feedback loop.
DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication.
Beta-Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5.
Early life gut microbiota sustains liver-resident natural killer cells maturation via the butyrate-IL-18 axis.
Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models.
NAD + salvage governs mitochondrial metabolism, invigorating natural killer cell antitumor immunity.
Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity
TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis.
Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation.
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response.
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation.
Zhx2 maintains islet β-cell mass and function by transcriptionally regulating Pax6.
Case report: Levodopa-responsive parkinsonism with akinetic mutism after ventriculo-peritoneal shunt
NAD+ salvage governs mitochondrial metabolism, invigorating natural killer cell antitumor immunity
Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis.