Area of research
Organic Chemistry · Molecular Biology
Research interest
Research interests include Multicomponent Synthesis of Heterocycles, Catalytic C–H Functionalization Methods, Protein Degradation and Inhibitors, and Synthesis and biological activity.
Lactam enables remote boronate rearrangements to C═N bonds.
Design, Synthesis, and Biological Evaluation of Thieno[3,2-<i>d</i>]pyrimidine Derivatives as the First Bifunctional PI3Kδ Isoform Selective/Bromodomain and Extra-Terminal Inhibitors.
Discovery of N-(3-fluorophenyl)-2-(4-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-yl)amino)phenyl)acetamide as the first orally active selective aurora kinase B inhibitor
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy.
An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L
IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation.
Overcoming Secondary Mutations of Type II Kinase Inhibitors.
Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective <i>via</i> Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss.
A novel isocyanide/Ag<sub>2</sub>CO<sub>3</sub>-promoted addition of heteroatoms to alkynes under mild conditions
Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose.
Dieckmann Condensation of Ugi <i>N</i>-Acylamino Amide Product: Facile Access to Functionalized 2,2-Disubstituted Indolin-3-ones.
Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction.
Discovery of fused benzimidazole-imidazole autophagic flux inhibitors for treatment of triple-negative breast cancer.
Zn(OTf)<sub>2</sub>-Promoted Isocyanide-Based Three-Component Reaction: Direct Access to 2-Oxazolines and β-Amino Amides.
Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation.
Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
Solvent‐Dependent Chemoselective and Stereoselective Approach to Synthesis of Spiro‐γ‐Lactams with Potent Anticancer Activity
Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors.
Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing-based molecular epidemiological study
Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology.
The Exploration of Chirality for Improved Druggability within the Human Kinome.
One-pot construction of functionalized aziridines and maleimides via a novel pseudo-Knoevenagel cascade reaction.
Microwave-Assisted Copper Catalysis of α-Difluorinated <i>gem</i>-Diol toward Difluoroalkyl Radical for Hydrodifluoroalkylation of <i>para</i>-Quinone Methides.
Spatiotemporal Dynamics of Intra-tumoral Dependence on NEK2-EZH2 Signaling in Glioblastoma Cancer Progression
Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases.
Strategy Used to Control the Mechanism of Homogeneous Alkyne/Olefin Hydrogenation: AIMD Simulations and DFT Calculations.
Correction to Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.