Area of research
Molecular Biology · Surgery
Research interest
Research interests include Congenital Diaphragmatic Hernia Studies, Chemical Synthesis and Analysis, Cancer-related gene regulation, and Epigenetics and DNA Methylation.
Reprogramming of TAMs via the STAT3/CD47-SIRPα axis promotes acquired resistance to EGFR-TKIs in lung cancer
Targeting Arginine Methyltransferase PRMT5 for Cancer Therapy: Updated Progress and Novel Strategies
Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer
The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance
Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?
Protein Arginine Methyltransferase 5 (PRMT5) as an Anticancer Target and Its Inhibitor Discovery
In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses
Structure–Property Relationship Studies of Influenza A Virus AM2-S31N Proton Channel Blockers
Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance
Selective N-terminal functionalization of native peptides and proteins
Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki–Miyaura Cross-Coupling Reaction
Application of Thiol–yne/Thiol–ene Reactions for Peptide and Protein Macrocyclizations
Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses
Discovery of Potent Antivirals against Amantadine-Resistant Influenza A Viruses by Targeting the M2-S31N Proton Channel
A Thiol–Ene Coupling Approach to Native Peptide Stapling and Macrocyclization
A Thiol–Ene Coupling Approach to Native Peptide Stapling and Macrocyclization
Metal-free, efficient hydrazination of imidazo[1,2-a]pyridine with diethyl azodicarboxylate in neutral media
Efficient Access to 2,3-Diarylimidazo[1,2-<i>a</i>]pyridines via a One-Pot, Ligand-Free, Palladium-Catalyzed Three-Component Reaction under Microwave Irradiation
Targeting Mutant KRAS for Anticancer Therapeutics: A Review of Novel Small Molecule Modulators
A p-toluenesulfinic acid-catalyzed three-component Ugi-type reaction and its application for the synthesis of α-amino amides and amidines