Area of research
Environmental Chemistry · Molecular Biology
Research interest
Research focused on DNA and Cell biology, with related work in Effector, Genetics, GTP'. Notable publications include 'The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop', 'In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C', and 'Real-time resolution of point mutations that cause phenovariance in mice'.
RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation
CircSMARCC1 and CircLRBA are potential biomarkers in forensic postmortem diagnosis of acute myocardial infarction
A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM
Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan
Inhibition of HMGB1 mediates neuroprotection of traumatic brain injury by modulating the microglia/macrophage polarization
Atypical activation of the G protein Gαq by the oncogenic mutation Q209P
Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog
Real-time resolution of point mutations that cause phenovariance in mice
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
The Bacterial Effector VopL Organizes Actin into Filament-like Structures