Area of research
Molecular Biology
Research interest
Research interests include Epigenetics and DNA Methylation, Histone Deacetylase Inhibitors Research, Ubiquitin and proteasome pathways, and Cancer-related gene regulation.
Histone deacetylase complexes: Structure, regulation and function
USP7 as an emerging therapeutic target: A key regulator of protein homeostasis
Discovery of 2-Aryl-4-aminoquinazolin-Based LSD1 Inhibitors to Activate Immune Response in Gastric Cancer
Triazole-fused pyrimidines in target-based anticancer drug discovery
Phenothiazine-Based LSD1 Inhibitor Promotes T-Cell Killing Response of Gastric Cancer Cells
Detailed curriculum vitae of HER2-targeted therapy
Neddylation-dependent LSD1 destabilization inhibits the stemness and chemoresistance of gastric cancer
Micafungin: A promising inhibitor of UBE2M in cancer cell growth suppression
Detailed resume of RNA m6A demethylases
Discovery of Novel Pyrazole-Based KDM5B Inhibitor <b>TK</b>-<b>129</b> and Its Protective Effects on Myocardial Remodeling and Fibrosis
Generation, secretion and degradation of cancer immunotherapy target PD-L1
The overview of Mitogen-activated extracellular signal-regulated kinase (MEK)-based dual inhibitor in the treatment of cancers
6-Heterocyclic carboxylic ester derivatives of gliotoxin lead to LSD1 inhibitors in gastric cancer cells
Myofibroblast Deficiency of LSD1 Alleviates TAC-Induced Heart Failure
Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing
Natural protoberberine alkaloids, identified as potent selective LSD1 inhibitors, induce AML cell differentiation
Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors
Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells
Synthesis of biologically relevant steroidal spiro β-lactams from dienamides through the cascade 4-endo N-cyclization/aerobic oxidation sequence
Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A)
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction
Potent and specific MTH1 inhibitors targeting gastric cancer
Derivative of 5-cyano-6-phenylpyrimidin antagonizes ABCB1- and ABCG2-mediated multidrug resistance
IL33 attenuates ventricular remodeling after myocardial infarction through inducing alternatively activated macrophages ethical standards statement
Targeting the DCN1–UBC12 Protein–Protein Interaction: Novel Approaches and Future Directions
Identification of osimertinib (AZD9291) as a lysine specific demethylase 1 inhibitor
Discovery of tranylcypromine analogs with an acylhydrazone substituent as LSD1 inactivators: Design, synthesis and their biological evaluation
TCPs: Privileged Scaffolds for Identifying Potent LSD1 Inhibitors for Cancer Therapy