Area of research
Molecular Biology · Organic Chemistry
Research interest
Research interests include Histone Deacetylase Inhibitors Research, Synthesis and biological activity, Epigenetics and DNA Methylation, and Peptidase Inhibition and Analysis.
Innovative Medicinal Chemistry Strategies for Improving Target Binding Kinetics in Drug Discovery
Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway
The m6A reader IGF2BP2 promotes the progression of esophageal squamous cell carcinoma cells by increasing the stability of OCT4 mRNA
Additional file 1 of Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway
Histone deacetylases (HDACs) as the promising immunotherapeutic targets for hematologic cancer treatment
Transcriptional dysregulation of TRIM29 promotes colorectal cancer carcinogenesis via pyruvate kinase-mediated glucose metabolism
Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects
Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors
Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A)
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction
Potent and specific MTH1 inhibitors targeting gastric cancer
Derivative of 5-cyano-6-phenylpyrimidin antagonizes ABCB1- and ABCG2-mediated multidrug resistance
Thiosemicarbazone-based selective proliferation inactivators inhibit gastric cancer cell growth, invasion, and migration
Identification of genomic alterations in oesophageal squamous cell cancer
A Chinese jujube (Ziziphus jujuba Mill.) fruit-expressed sequence tag (EST) library: Annotation and EST-SSR characterization