Area of research
Molecular Biology · Oncology
Research interest
Research interests include DNA Repair Mechanisms, Peptidase Inhibition and Analysis, Cancer, Hypoxia, and Metabolism, and Ubiquitin and proteasome pathways.
Enabling the immune escaped etesevimab fully-armed against SARS-CoV-2 Omicron subvariants including KP.2
A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy
Oncogenic KRAS Induces Arginine Auxotrophy and Confers a Therapeutic Vulnerability to SLC7A1 Inhibition in Non–Small Cell Lung Cancer
Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota
Low‐Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells
Exosomes derived from endothelial progenitor cells ameliorate LPS-induced brain microvascular endothelial cells injury by delivering miR-126a-5p
Depletion of regulatory T cells enhancing the anti-tumor effect of in situ vaccination in solid tumors
Small-molecule agents for cancer immunotherapy
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma
Bile acids promote the development of HCC by activating the inflammasome
PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders
Identification of immune-related signatures and pathogenesis differences between thoracic aortic aneurysm patients with bicuspid versus tricuspid valves via weighted gene co-expression network analysis
Integration of metabolomics and transcriptomics to reveal ferroptosis is involved in Tripterygium wilfordii polyglycoside tablet-induced testicular injury
Discovery of PHGDH inhibitors by virtual screening and preliminary structure–activity relationship study
Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression
Discovery of Novel Pyrrolo[2,3-<i>d</i>]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors
Screening tumor specificity targeted by arnicolide D, the active compound of Centipeda minima and molecular mechanism underlying by integrative pharmacology
Mechanism of &lt;italic&gt;Coptis chinensis&lt;/italic&gt; in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking
Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy
ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells
Could Ultrasound‐Based Radiomics Noninvasively Predict Axillary Lymph Node Metastasis in Breast Cancer?
Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans
A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies
Identification of a new inhibitor of KRAS‐PDEδ interaction targeting KRAS mutant nonsmall cell lung cancer
Cryo-EM structure of human mTOR complex 2
Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity
Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma
CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development
4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1