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Jason Chen

BGI Group (China) · CN
Area of research
Molecular Biology · Materials Chemistry
Research interest
Research interests include PI3K/AKT/mTOR signaling in cancer, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, and Chemical Synthesis and Analysis.
h-index
42
citations
8,024
works
294
NIH funding
primary concept
email

Recent publications

The Case for Neurosurgical Intervention in Cancer Neuroscience
Neurosurgery 2024cited by 6position: middledoi
Landmine Injury Resulting in Comminuted Lumbar Facet Fracture as a Cause of Lumbar Stenosis and Spondylolisthesis.
2024cited by 0position: contributordoi
Delayed Rupture of an Anterior Communicating Artery Aneurysm After Elective Woven Endobridge Embolization, Re-Treated With Microsurgical Clipping: Operative Technique and Systematic Review.
2022cited by 3position: contributordoi
Transcranial MR-Guided Focused Ultrasound and Hyperostosis Calvariae Diffusa: Case Report and Systematic Review of the Literature.
2022cited by 3position: contributordoi
Metformin Attenuates Renal Fibrosis in a Mouse Model of Adenine-Induced Renal Injury Through Inhibiting TGF-β1 Signaling Pathways
Frontiers in Cell and Developmental Biology 2021cited by 60position: middledoi
Artificial Intelligence in the Management of Glioma: Era of Personalized Medicine
Frontiers in Oncology 2019cited by 109position: middledoi
A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors
Neuron 2019cited by 95position: middledoi
Genome‐wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy
Movement Disorders 2019cited by 42position: middledoi
Genome-wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy.
2019cited by 30position: contributordoi
Treatment-refractory Escherichia coli subdural empyema caused by infection of a chronic subdural hematoma in an infant.
2019cited by 4position: contributordoi
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
Nature Medicine 2018cited by 584position: middledoi
Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases
Molecular Neurodegeneration 2018cited by 137position: firstdoi
Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer
Clinical Cancer Research 2018cited by 101position: middledoi
Neurodegenerative disease biomarkers Aβ<sub>1–40</sub>, Aβ<sub>1–42</sub>, tau, and p‐tau<sub>181</sub> in the vervet monkey cerebrospinal fluid: Relation to normal aging, genetic influences, and cerebral amyloid angiopathy
Brain and Behavior 2018cited by 51position: firstdoi
Cerebellar tonsil ectopia measurement in type I Chiari malformation patients show poor inter-operator reliability
Fluids and Barriers of the CNS 2018cited by 26position: middledoi
Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome
Neuron 2017cited by 181position: middledoi
A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction
Brain 2017cited by 115position: middledoi
Machine learning for large‐scale wearable sensor data in Parkinson's disease: Concepts, promises, pitfalls, and futures
Movement Disorders 2016cited by 216position: middledoi
Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma
Scientific Reports 2016cited by 166position: middledoi
Mouse Models of Diabetes, Obesity and Related Kidney Disease
PLoS ONE 2016cited by 150position: middledoi
SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β
Journal of Neuroscience 2015cited by 273position: middledoi
The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology
Annual Review of Pathology Mechanisms of Disease 2015cited by 261position: firstdoi
A Multiancestral Genome-Wide Exome Array Study of Alzheimer Disease, Frontotemporal Dementia, and Progressive Supranuclear Palsy
JAMA Neurology 2015cited by 44position: firstdoi
Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations
Nature Communications 2014cited by 587position: middledoi
An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy
PLoS Genetics 2014cited by 96position: middledoi
Reductions in Brain 5-HT1B Receptor Availability in Primarily Cocaine-Dependent Humans
Biological Psychiatry 2013cited by 88position: middledoi
Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice
Diabetes 2013cited by 86position: middledoi
Succinate dehydrogenase-deficient GISTs are characterized by IGF1R overexpression
Modern Pathology 2012cited by 55position: middledoi

Grants

EAGER: Collaborative Research: Networking Faculty Seeds for Collective Change in the Geosciences
NSF2039251$134,8492020–2023PIRePORTER
Collaborative Research: GEODES: Geoscience Diversity Experiential Simulations
NSF1645444$196,0072017–2020PIRePORTER
CAREER: Stereochemically-Flexible Polyol Synthesis
NSF1453896$106,5522015–2017PIRePORTER

Frequent collaborators

Giovanni Coppola · Regeneron (United States)7 papers (2014–2019)Daniel H. Geschwind · University of Southern California5 papers (2014–2019) · 4 papers (2019–2024)Alden Huang · University of California, Los Angeles3 papers (2018–2019)Carol A. Pollock · Macquarie University3 papers (2013–2021)Adam L. Boxer · Brunel University of London3 papers (2014–2018)Xinming Chen · Institute of Space Sciences2 papers (2013–2021) · 2 papers (2018–2019)Jean‐François Dartigues · Université de Bordeaux2 papers (2018–2019) · 2 papers (2018–2019)Joshua D. Bernstock · University of Alabama at Birmingham2 papers (2019–2024)Jeff M. Bronstein · VA West Los Angeles Medical Center2 papers (2018–2019)Kevin Wojta · University of California, Los Angeles2 papers (2017–2018)Anthony J. Gill · The University of Sydney2 papers (2012–2013)Jennifer K. Lowe · University of California, Los Angeles2 papers (2018–2019)Philippe Amouyel · Laboratoire Epidémiologie et Analyses en Santé Publique : Risques, Maladies Chroniques et Handicaps2 papers (2018–2019)Fuying Gao · University of California, Los Angeles2 papers (2014–2015)Ammar Al‐Chalabi · Cambridge University Hospitals NHS Foundation Trust2 papers (2018–2019)Chunling Huang · Fujian Medical University2 papers (2013–2021)Cathryn M. Lewis · King's College London2 papers (2018–2019)