Area of research
Molecular Biology · Immunology
Research interest
Research interests include Epigenetics and DNA Methylation, RNA modifications and cancer, Genomics and Chromatin Dynamics, and Immune Cell Function and Interaction.
Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy
Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke
Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium
Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors
Proteasomal processing of the viral replicase ORF1 facilitates HEV-induced liver fibrosis
pORF3-driven biogenesis of lipid droplets facilitates HEV infectivity
Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors
787P First-in-human, phase I study of CBP-1008, a first-in-class bi-specific ligand drug conjugate (Bi-XDC), in patients with advanced solid tumors
Lipid-anchored Proteasomes Control Membrane Protein Homeostasis
Challenges of photocatalysis and their coping strategies
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses
Hippo signaling pathway activation during SARS-CoV-2 infection contributes to host antiviral response
Pathological Networks Involving Dysmorphic Neurons in Type II Focal Cortical Dysplasia
In vivo development and single‐cell transcriptome profiling of human brain organoids
Integration of evidence across human and model organism studies: A meeting report
HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity
Double-Edged Sword of Tumour Suppressor Genes in Schizophrenia
ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions
Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development
Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules
The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting
Serum-Based Culture Conditions Provoke Gene Expression Variability in Mouse Embryonic Stem Cells as Revealed by Single-Cell Analysis
Haploinsufficiency, but Not Defective Paternal 5mC Oxidation, Accounts for the Developmental Defects of Maternal Tet3 Knockouts
Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer’s Disease
Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation
Mechanism and Function of Oxidative Reversal of DNA and RNA Methylation
Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes
Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing
Genome-wide Analysis Reveals TET- and TDG-Dependent 5-Methylcytosine Oxidation Dynamics
Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes
Collaborative Research: SCH: Personal Determinants of Health Enhanced Machine Learning Models for Early Prediction of Alzheimer's Disease and Related Dementias
BIGDATA: IA: Collaborative Research: Asynchronous Distributed Machine Learning Framework for Multi-Site Collaborative Brain Big Data Mining
SCH: INT: Mining Drug-Drug Interaction Induced Adverse Effects from Health Record Databases
SCH: INT: Mining Drug-Drug Interaction Induced Adverse Effects from Health Record Databases
III: Small: Collaborative Research: A Large-Scale Data Mining Framework for Genome-Wide Mapping of Multi-Modal Phenotypic Biomarkers and Outcome Prediction