Area of research
Molecular Biology · Public Health, Environmental and Occupational Health · kuma
Research interest
Research interests include Epigenetics and DNA Methylation, Reproductive Biology and Fertility, Prenatal Screening and Diagnostics, and Genetic Syndromes and Imprinting.
Generation of germinal-vesicle oocytes from mouse embryonic stem cells under an ovarian soma-free condition.
Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells
Loss of Ikbkap/Elp1 in mouse oocytes causes spindle disorganization, developmental defects in preimplantation embryos and impaired female fertility
Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent
Maternal H3K27me3 controls DNA methylation-independent imprinting
Maternal H3K27me3 controls DNA methylation-independent imprinting
Establishing Chromatin Regulatory Landscape during Mouse Preimplantation Development
Haploinsufficiency, but Not Defective Paternal 5mC Oxidation, Accounts for the Developmental Defects of Maternal Tet3 Knockouts
Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation
Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes
Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes
siRNA-mediated depletion of stable proteins in mouse oocytes
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
Tet1 controls meiosis by regulating meiotic gene expression
Transcriptional activation of transposable elements in mouse zygotes is independent of Tet3-mediated 5-methylcytosine oxidation