Area of research
Oncology · Molecular Biology
Research interest
Research interests include Chemokine receptors and signaling, Cell death mechanisms and regulation, Immunotherapy and Immune Responses, and HIV Research and Treatment.
Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists
Palmitic acid enhances the sensitivity of ferroptosis via endoplasmic reticulum stress mediated the ATF4/TXNIP Axis in polycystic ovary syndrome
Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease
Structure-guided discovery of a small molecule inhibitor of SARS-CoV-2 main protease with potent <i>in vitro</i> and <i>in vivo</i> antiviral activities
Sulfonation metabolism in the gut microbiota is the main metabolic pathway of cholesterol in hypercholesterolemic mice
Xinbao pill attenuated water retention by regulating the CaSR/AQP2 pathway in LAD-induced chronic heart failure rats
A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV-2 in Cells
Xinbao Pill attenuated chronic heart failure by suppressing the ubiquitination of β-adrenergic receptors
Camellia oleifera Oil Body as a Delivery System for Curcumin: Encapsulation, Physical, and in Vitro Digestion Properties
Potential Therapeutic Strategies for Skeletal Muscle Atrophy
Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy
Inhibition of IL-6/JAK/STAT3 pathway rescues denervation-induced skeletal muscle atrophy
Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation
Aspirin alleviates denervation-induced muscle atrophy via regulating the Sirt1/PGC-1α axis and STAT3 signaling
Discoveries and developments of CXCR4-targeted HIV-1 entry inhibitors
Microarray Analysis of Gene Expression Provides New Insights Into Denervation-Induced Skeletal Muscle Atrophy
Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation
PQQ ameliorates skeletal muscle atrophy, mitophagy and fiber type transition induced by denervation via inhibition of the inflammatory signaling pathways
miR-125b-5p targeting TRAF6 relieves skeletal muscle atrophy induced by fasting or denervation
High affinity CXCR4 inhibitors generated by linking low affinity peptides
Discovery and Computational Analyses of Novel Small Molecule Zika Virus Inhibitors
Strategies and potential therapeutic agents to counter skeletal muscle atrophy
Virtual Screening, Biological Evaluation, and 3D-QSAR Studies of New HIV-1 Entry Inhibitors That Function via the CD4 Primary Receptor