Area of research
Virology · Infectious Diseases
Research interest
Research interests include HIV Research and Treatment, Immune Cell Function and Interaction, SARS-CoV-2 and COVID-19 Research, and HIV/AIDS drug development and treatment.
The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments
Development of a PCSK9-targeted nanoparticle vaccine to effectively decrease the hypercholesterolemia
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis
Enhancement of CAR‐T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins
A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross‐Protection Activity against Multiple SARS‐CoV‐2 Sublineages
Nanobody-derived bispecific CAR-T cell therapy enhances the anti-tumor efficacy of T cell lymphoma treatment
Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L
CBX4 contributes to HIV‐1 latency by forming phase‐separated nuclear bodies and SUMOylating EZH2
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι
The CD39+ HBV surface protein-targeted CAR-T and personalized tumor-reactive CD8+ T cells exhibit potent anti-HCC activity
Broadly neutralizing antibody–derived CAR T cells reduce viral reservoir in individuals infected with HIV-1
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19
Two waves of pro-inflammatory factors are released during the influenza A virus (IAV)-driven pulmonary immunopathogenesis
Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56
TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb
Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation
IL-4 Inhibits the Biogenesis of an Epigenetically Suppressive PIWI-Interacting RNA To Upregulate CD1a Molecules on Monocytes/Dendritic Cells
A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes