Area of research
Animal Science and Zoology · Physiology
Research interest
Research topics from publications: Toxicity, biodegradation, and nutritional intervention mechanism of zearalenone; Enhancement of gut barrier integrity by a Bacillus subtilis secreted metabolite through the GADD45A‐Wnt/β‐catenin pathway. Representative work: Abstract Inflammatory bowel disease (IBD) represents a significant challenge to global health, characterized by intestinal inflammation, impaired barrier function, and dysbiosis, with limited therapeutic options. In this study, we isolated a novel strain of Bacillus subtilis ( B. subtilis ) and observed promising effects in protecting against disruption of the gut barrier. Our findings indicate that the enhancement of intestinal barrier function is primarily attributed to its metabolites. We identified a novel metabolite, 2‐hydroxy‐4‐methylpentanoic acid (HMP), derived from B. subtilis , that significantly improved intestinal barrier function. We also show that growth arrest and DNA damage 4