Area of research
Neurology · Biological Psychiatry
Research interest
Research focused on Microglia and Neuroinflammation, with related work in Farnesoid X receptor, Hippocampal formation, Protein kinase B. Notable publications include 'The ketone body metabolite β‐hydroxybutyrate induces an antidepression‐associated ramification of microglia via HDACs inhibition‐triggered Akt‐small RhoGTPase activation', 'Identification of functional farnesoid X receptors in brain neurons', and 'Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses'.
Nicotine exposure in adolescence triggers the activation and subsequent damage of microglia in the dentate gyrus and promotes depression later in life
The immunoregulator β-glucan produces antidepressant effects through microglia-mobilized astrocytic P2Y1R-BDNF signaling in the dentate gyrus
Stimulation of microglia in adolescence produces a long-lasting prophylactic effect on single prolonged stress-induced PTSD-like behavior in adult mice
Intranasal LAG3 antibody infusion induces microglia-dependent antidepressant effect by mobilizing astrocytic P2Y1R-mediated BDNF synthesis in the hippocampus
Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence
Central innate immunization induces tolerance against post-traumatic stress disorder-like behavior and neuroinflammatory responses in male mice
Microglia stimulation produces antidepressant-like effects in a mouse depression model induced by adolescent chronic unpredictable stress
Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice
Microglia-Dependent Reversal of Depression-Like Behaviors in Chronically Stressed Mice by Administration of a Specific Immuno-stimulant β-Glucan
[Retracted] Taurine Ameliorates Iron Overload‐Induced Hepatocyte Injury via the Bcl‐2/VDAC1‐Mediated Mitochondrial Apoptosis Pathway
Poncirin ameliorates cardiac ischemia-reperfusion injury by activating PI3K/AKT/PGC-1α signaling
Vanillic Acid Alleviates Acute Myocardial Hypoxia/Reoxygenation Injury by Inhibiting Oxidative Stress
Farnesoid X Receptor-Mediated Cytoplasmic Translocation of CRTC2 Disrupts CREB-BDNF Signaling in Hippocampal CA1 and Leads to the Development of Depression-Like Behaviors in Mice
Identification of a microglial activation-dependent antidepressant effect of amphotericin B liposome
Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation
Tauroursodeoxycholic acid produces antidepressant‐like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido‐nitrosative stress, and endoplasmic reticulum stress
The ketone body metabolite β‐hydroxybutyrate induces an antidepression‐associated ramification of microglia via HDACs inhibition‐triggered Akt‐small RhoGTPase activation
Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses
Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition
Current pharmacological developments in 2,3,4′,5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG)
Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway
Methylene blue increases the amount of HSF1 through promotion of PKA-mediated increase in HSF1-p300 interaction
Mechanism of 2,3,4',5-Tetrahydroxystilbene 2-O-β-<smlcap>D</smlcap>-Glucoside-Induced Upregulation of Glutamate Transporter 1 Protein Expression in Mouse Primary Astrocytes
Identification of functional farnesoid X receptors in brain neurons
WY-14643, a selective agonist of peroxisome proliferator-activated receptor-α, ameliorates lipopolysaccharide-induced depressive-like behaviors by preventing neuroinflammation and oxido-nitrosative stress in mice
Z-guggulsterone negatively controls microglia-mediated neuroinflammation via blocking IκB-α–NF-κB signals