Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include RNA modifications and cancer, Cancer-related molecular mechanisms research, CRISPR and Genetic Engineering, and Ferroptosis and cancer prognosis.
Exploring the heterogeneous targets of metabolic aging at single-cell resolution.
Stimulation of microglia leads to a rapid antidepressant effect by triggering astrocytic P2Y1Rs and promoting BDNF-mediated neurogenesis in the hippocampus
The X-Age Project to construct a Chinese aging clock.
Nascent RNA at the crossroad of transcription and replication
Gene therapy strategies for aging intervention.
Stimulation of microglia in adolescence produces a long-lasting prophylactic effect on single prolonged stress-induced PTSD-like behavior in adult mice
Transcription-replication conflict resolution by nuclear RNA interference
Dcr1 senses R-loops for RNAPII termination at sites of replication stress and repair pathway choice
A fungi-derived cyclic peptide enhances Th9-mediated antitumor immunity by targeting ZAP70 and SREBP1
DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability
Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements
Targeting aging and age-related diseases with vaccines.
Single phage proteins sequester signals from TIR and cGAS-like enzymes
Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence
Expert consensus on perioperative integrated skincare for noninvasive energy‐based device aesthetic procedures in clinical practice in China
Mitochondrial aberrations in systemic lupus erythematosus pathogenesis: Insights and therapeutic implications
Perspectives on biomarkers of reproductive aging for fertility and beyond.
Global insights into aging: a multidisciplinary approach to understanding and addressing age-related challenges.
Microglia stimulation produces antidepressant-like effects in a mouse depression model induced by adolescent chronic unpredictable stress
Immunization with a low dose of zymosan A confers resistance to depression-like behavior and neuroinflammatory responses in chronically stressed mice
Effects of intravenous anesthesia and inhalation anesthesia on postoperative inflammatory markers in patients with esophageal cancer: a retrospective study
Resurrection of endogenous retroviruses during aging reinforces senescence
Bacteriophages inhibit and evade cGAS-like immune function in bacteria
m<sup>6</sup>A epitranscriptomic regulation of tissue homeostasis during primate aging.
CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord.
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
The Aging Biomarker Consortium represents a new era for aging research in China
A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium
Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides