Area of research
Molecular Biology · Urology
Research interest
Research focused on Mesenchyme and Cell biology, with related work in Wnt signaling pathway, Retinal degeneration, GDF15. Notable publications include 'Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development', 'Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a...', and 'Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung'.
Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs
<i>Uridine diphosphate-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase</i>deletion in mice leads to lethal intracerebral hemorrhage during embryonic development
A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification
Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells
A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development
Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations
A Dominant Mutation in Nuclear Receptor Interacting Protein 1 Causes Urinary Tract Malformations via Dysregulation of Retinoic Acid Signaling
BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter
Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung
Diversification of Cell Lineages in Ureter Development
Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development
Whole-exome sequencing identifies mutations of TBC1D1 encoding a Rab-GTPase-activating protein in patients with congenital anomalies of the kidneys and urinary tract (CAKUT)
Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling
Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate
Inhibition of Sox2-dependent activation of <i>Shh</i> in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis
Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter