Area of research
Physiology · Cellular and Molecular Neuroscience
Research interest
Research interests include Alzheimer's disease research and treatments, Neuroscience and Neuropharmacology Research, Cholinesterase and Neurodegenerative Diseases, and Monoclonal and Polyclonal Antibodies Research.
TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model
Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer’s Disease
Klotho controls the brain–immune system interface in the choroid plexus
Istradefylline reduces memory deficits in aging mice with amyloid pathology
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory
DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice
Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice
Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β
Network dysfunction in<i>α</i>‐synuclein transgenic mice and human Lewy body dementia
Life Extension Factor Klotho Enhances Cognition
Tau reduction prevents disease in a mouse model of <scp>D</scp>ravet syndrome
Tau Reduction Diminishes Spatial Learning and Memory Deficits after Mild Repetitive Traumatic Brain Injury in Mice
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β
Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model
Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits