Area of research
Molecular Biology · Epidemiology
Research interest
Research topics from publications: Mechanism of subchronic vinyl chloride exposure combined with a high‐fat diet on hepatic steatosis. Representative work: Abstract Vinyl chloride (VC) is a common industrial organic chlorine and environmental pollutant. In recent years, the dietary structure of residents especially Chinese has gradually shifted to western dietary patterns. VC aggravates dietary fatty acid‐induced hepatic steatosis, but its mechanism is still unclear. And if the risk factors for steatosis persist, more severe diseases such as fibrosis and cirrhosis will occur. Therefore, we studied the effects and mechanisms of VC (160 and 800 mg/m 3 ) and its metabolite (chloroacetaldehyde, 2.25, 4.5, and 9 μM) on hepatic steatosis of high‐fat diet (HFD)‐fed mice and palmitic acid (PA, 100 μM) treated HepG2 cells. Liver and serum biochemical in