Area of research
Neurology · Physiology
Research interest
Research interests include Parkinson's Disease Mechanisms and Treatments, Alzheimer's disease research and treatments, Neurological Disorders and Treatments, and Neuroinflammation and Neurodegeneration Mechanisms.
Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies
Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease
Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation
LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons <i>in vivo</i>
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
RETRACTED ARTICLE: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
RETRACTED ARTICLE: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
RETRACTED: Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy
Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans
The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons
Possible Involvement of Adiponectin, the Anti-Diabetes Molecule, in the Pathogenesis of Alzheimer’s Disease
Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson’s disease
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis
HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders
Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease
Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
RETRACTED: Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration <i>in vivo</i>
Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
RETRACTED: ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats
TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease
Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice