Area of research
Neurology · Physiology
Research interest
Research interests include Parkinson's Disease Mechanisms and Treatments, Neurological Disorders and Treatments, Alzheimer's disease research and treatments, and Cholinesterase and Neurodegenerative Diseases.
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention
Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells
Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation
LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
RETRACTED ARTICLE: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
RETRACTED ARTICLE: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
RETRACTED: Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis
Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson’s disease
Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
RETRACTED: Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration <i>in vivo</i>
TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease
Antidepressants reduce neuroinflammatory responses and astroglial alpha‐synuclein accumulation in a transgenic mouse model of multiple system atrophy
S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease
Widespread micro<scp>RNA</scp>dysregulation in multiple system atrophy – disease‐related alteration in miR‐96
Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer
Role of α-Synuclein in Adult Neurogenesis and Neuronal Maturation in the Dentate Gyrus
Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model
Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease
Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease