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Yong Chen

First Affiliated Hospital of Hunan University of Traditional Chinese Medicine · CN
Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Cancer-related molecular mechanisms research, Genomics and Chromatin Dynamics, RNA modifications and cancer, and Cancer-related gene regulation.
h-index
64
citations
18,263
works
525
NIH funding
primary concept
email

Recent publications

WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity
Nature Communications 2026cited by 1position: contributordoi
Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR): a retrospective cohort study
The Lancet Infectious Diseases 2025cited by 13position: lastdoi
Zinc ions activate AKT and promote prostate cancer cell proliferation via disrupting AKT intramolecular interaction.
2025cited by 5position: contributordoi
Cost-effectiveness analysis of sugemalimab combined with chemotherapy as first-line treatment for advanced gastric cancer
Frontiers in Public Health 2025cited by 4position: middledoi
Targeting VGLL4 maintains extracellular matrix homeostasis and mitigates osteoarthritis in a preclinical model
Nature Communications 2025cited by 3position: contributordoi
PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma
Genes & Diseases 2025cited by 1position: contributordoi
The Influence and Mechanisms of Natural Plant Polysaccharides on Intestinal Microbiota-Mediated Metabolic Disorders
Foods 2024cited by 38position: firstdoi
DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells
Nature Communications 2024cited by 10position: middledoi
DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells.
2024cited by 9position: contributordoi
The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B
Nature Communications 2024cited by 2position: contributordoi
BAF155 promotes cardiac hypertrophy and fibrosis through inhibition of WWP2-mediated PARP1 ubiquitination
Cell Discovery 2023cited by 18position: contributordoi
Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1
Nature Communications 2023cited by 14position: contributordoi
Author Correction: Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1
Nature Communications 2023cited by 2position: contributordoi
Mechanism of symbiotic nodulation between nitrogen and peanut.
PubMed 2023cited by 1position: middledoi
FTO in cancer: functions, molecular mechanisms, and therapeutic implications
Trends in cancer 2022cited by 238position: middledoi
NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis
Journal of Hepatology 2022cited by 56position: middledoi
Effects of selenylation modification on the antioxidative and immunoregulatory activities of polysaccharides from the pulp of Rose laevigata Michx fruit
International Journal of Biological Macromolecules 2022cited by 52position: middledoi
Global profiling of regulatory elements in the histone benzoylation pathway.
2022cited by 13position: contributordoi
The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications
Protein & Cell 2022cited by 9position: contributordoi
DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates
iScience 2022cited by 8position: contributordoi
Development and Application of InDel Markers Linked to Fruit-Shape and Peel-Colour Genes in Wax Gourd
Genes 2022cited by 8position: middledoi
Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
Nature Communications 2021cited by 40position: contributordoi
Dri1 mediates heterochromatin assembly via RNAi and histone deacetylation
Genetics 2021cited by 9position: contributordoi
Monoseeding Increases Peanut (Arachis hypogaea L.) Yield by Regulating Shade-Avoidance Responses and Population Density
Plants 2021cited by 2position: middledoi
Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9
Genome biology 2020cited by 55position: middledoi
Overexpression of long non-coding RNA Rian attenuates cell apoptosis from cerebral ischemia-reperfusion injury via Rian/miR-144-3p/GATA3 signaling
Gene 2020cited by 41position: middledoi
Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation
Nature Communications 2020cited by 25position: contributordoi
Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly
Nature Communications 2020cited by 19position: contributordoi
Brucine Inhibits Proliferation of U87 Glioblastoma Cells by Targeting the G-quadruplexes in the c-Myb Promoter
Research Square 2020cited by 1position: middledoi
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44
Nature 2019cited by 537position: middledoi

Grants

EPSCoR Graduate Fellowship Program (EGFP): Graduate Leaders in Engineering and Advanced Manufacturing (GLEAM): Enhancing Iowa's Manufacturing Capacity
NSF2500269$1,272,0002025–2028PIRePORTER
Collaborative Research: Quantum Algorithms for High-Performance Analysis of Single-Cell Omics Data and Explainable Drug Discovery
NSF2531954$200,0002025–2027PIRePORTER
Category II: REPACSS: Empowering Scientific Discovery through Renewable Energy Powered Advanced Computing Systems and Services
NSF2404438$12,249,9992024–2029PIRePORTER
Collaborative Research: Fusion of Siloed Data for Multistage Manufacturing Systems: Integrative Product Quality and Machine Health Management
NSF2323084$207,1582024–2026PIRePORTER
CAREER: Statistical Models and Parallel-computing Methods for Analyzing Sparse and Large Single-cell Chromatin Interaction Datasets
NSF2239350$559,2512023–2028PIRePORTER
Conference: 2024 Manufacturing Science and Engineering Conference and 52nd North American Manufacturing Research Conference; Knoxville, Tennessee; 17-21 June 2024
NSF2344983$49,6002023–2024PIRePORTER
Phase-II IUCRC Texas Tech University: Center for Cloud and Autonomic Computing
NSF1939140$1,498,5902020–2027PIRePORTER
Quantum Many-Body Physics in Spin-Orbit Coupled Bose Gases
NSF2012185$357,7362020–2024PIRePORTER
Elements:Software:NSCI: Empowering Data-driven Discovery with a Provenance Collection, Management, and Analysis Software Infrastructure
NSF1835892$599,9822018–2024PIRePORTER
CSR: Small: Collaborative Research: Tuning Extreme-scale Storage Stack through Deep Reinforcement Learning
NSF1817094$240,0262018–2024PIRePORTER
Collaborative Research: CESER: EAGER: "FabWave" - A Pilot Manufacturing Cyberinfrastructure for Shareable Access to Information Rich Product Manufacturing Data
NSF1812675$108,6252018–2020PIRePORTER
Additive Manufacturing of Controlled Anisotropic Materials via Electrically Assisted Nanocomposite Fabrication
NSF1663663$315,8402017–2021PIRePORTER
Dynamics and Excitations of Spin-Orbit-Coupled Bose-Einstein Condensates
NSF1708134$300,0002017–2021PIRePORTER
SHF: Small: Collaborative Research: Uncovering Vulnerabilities in Parallel File Systems for Reliable High Performance Computing
NSF1718336$233,0002017–2023PIRePORTER
Collaborative Research: Strain Based Devices for Switches and Memory Applications
NSF1711332$210,0002017–2021PIRePORTER
EFRI NewLaw: Controlling Thermal Transport with Topologically Guided Heat Carriers
NSF1641101$1,963,9392016–2021PIRePORTER
SHF: Medium: Compute on Data Path: Combating Data Movement in High Performance Computing
NSF1409946$1,016,0002014–2021PIRePORTER
Majorana particles in topological insulator quantum wires
NSF1410942$420,0002014–2017PIRePORTER
SCH: EXP: Collaborative Research: Smart Asthma Management: Statistical Modeling, Prognostics, and Intervention Decision Making
NSF1343974$200,5212014–2018PIRePORTER
Travel Support for The 14th IEEE/ACM International Symposium on Cluster, Cloud and Grid Computing
NSF1430856$10,0002014–2015PIRePORTER
MRI Collaborative: Development of a Data-Intensive Scalable Computing Instrument for High Performance Computing
NSF1338078$532,0002013–2018PIRePORTER
REU Site: Research Experiences for Undergraduates in Cybersecurity, Robotics, and Software Engineering
NSF1263183$357,3372013–2016PIRePORTER
GOALI: Novel Piezoelectric Device Fabrication Using Digital Projection based Additive Manufacturing
NSF1335476$300,0352013–2017PIRePORTER
GOALI/Collaborative Research: Data-Driven Statistical Prognosis and Service Decision Making for Teleservice Systems
NSF1335454$150,0002013–2016PIRePORTER

Frequent collaborators

· 17 papers (2019–2026)Ming Lei · Shanghai Jiao Tong University6 papers (2012–2017)Sandy Chang · Yale Cancer Center4 papers (2020–2023)Sandy Chang · Yale University4 papers (2020–2023)Yali Dou · University of Southern California4 papers (2012–2017)Shaomeng Wang · Rogers (United States)4 papers (2012–2017)Hacer Karataş · West Virginia University3 papers (2012–2017)Bingbing Wan · Memorial Sloan Kettering Cancer Center3 papers (2012–2014)Liu Liu · Kunming Medical University3 papers (2014–2017)Jianlong Wang · Columbia University Irving Medical Center3 papers (2024–2026)Yanjing Li · Institute of Biochemistry and Cell Biology2 papers (2024–2026) · 2 papers (2024–2026)Jinlong Suo · Clarivate PLC2 papers (2025–2026)Amer Al-Hiyasat · Massachusetts Institute of Technology2 papers (2023–2023)Hui Cao · Southwestern Medical Center2 papers (2017–2020)Wei Kuang · Nanchang University2 papers (2017–2017)Denzil Bernard · Healthwise2 papers (2012–2017)Shirley Lee · Universiti Brunei Darussalam2 papers (2014–2017)Fang Cao · Qilu University of Technology2 papers (2014–2017)Guowen Hu · First People's Hospital of Foshan2 papers (2017–2017)