Area of research
Physiology · Genetics
Research interest
Research focused on Genome-wide association study and Disease, with related work in Genetics, Alzheimer's disease, Single-nucleotide polymorphism. Notable publications include 'Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease', 'Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing', and 'New insights into the genetic etiology of Alzheimer’s disease and related dementias'.
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations
Machine learning in Alzheimer’s disease genetics
X‐chromosome-wide association study for Alzheimer’s disease
Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by <i>HLA-DRB1*04</i> subtypes
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
Association of Rare <i>APOE</i> Missense Variants V236E and R251G With Risk of Alzheimer Disease
Association of <i>APOE</i> -Independent Alzheimer Disease Polygenic Risk Score With Brain Amyloid Deposition in Asymptomatic Older Adults
Protective association of <i>HLA‐DRB1</i>*04 subtypes in neurodegenerative diseases implicates acetylated tau PHF6 sequences
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
Plasma amyloid β levels are driven by genetic variants near <i>APOE, BACE1, APP, PSEN2</i>: A genome‐wide association study in over 12,000 non‐demented participants
Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis
New insights on the genetic etiology of Alzheimer’s and related dementia
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Association of variants in<i>HTRA1</i>and<i>NOTCH3</i>with MRI-defined extremes of cerebral small vessel disease in older subjects
Analysis of shared heritability in common disorders of the brain
Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
Tau deletion promotes brain insulin resistance
Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits
Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy
A novel Alzheimer disease locus located near the gene encoding tau protein
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Convergent genetic and expression data implicate immunity in Alzheimer's disease