Area of research
Molecular Biology · Genetics
Research interest
Research interests include Glioma Diagnosis and Treatment, Hedgehog Signaling Pathway Studies, Chromatin Remodeling and Cancer, and Cancer-related molecular mechanisms research.
Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma
ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip
Targeting TET3 suppresses group 3 medulloblastoma stemness and progression via impairing hypomethylation of Otx2 super-enhancer
Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma
The transcriptional landscape of Shh medulloblastoma
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
Childhood cerebellar tumours mirror conserved fetal transcriptional programs
Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma
<i>Sleeping Beauty</i> Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors
A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases
The whole-genome landscape of medulloblastoma subtypes
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Spatial heterogeneity in medulloblastoma
Divergent clonal selection dominates medulloblastoma at recurrence
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target
Medulloblastoma subgroups remain stable across primary and metastatic compartments
Cytogenetic Prognostication Within Medulloblastoma Subgroups
The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma
Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Clonal selection drives genetic divergence of metastatic medulloblastoma
Functional Genomics Identifies Drivers of Medulloblastoma Dissemination
Abstract 1428: A CpG island methylator phenotype defines a clinically aggressive subgroup of posterior fossa ependymoma