Area of research
Genetics · Molecular Biology
Research interest
Research interests include Virus-based gene therapy research, CRISPR and Genetic Engineering, CAR-T cell therapy research, and RNA Interference and Gene Delivery.
Retroviral gene therapy in Germany with a view on previous experience and future perspectives
Lentiviral gene therapy for X-linked chronic granulomatous disease
Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for <i>Ex Vivo</i> Gene Therapy of X-Linked Chronic Granulomatous Disease
Compatibility of RUNX1/ETO fusion protein modules driving CD34+ human progenitor cell expansion
Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization
Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions
Advantages and applications of CAR-expressing natural killer cells
A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells
TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells
High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies
Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny
Clonal analysis of multipotent stromal cells derived from CD271+ bone marrow mononuclear cells: functional heterogeneity and different mechanisms of allosuppression
From Bench to Bedside: Preclinical Evaluation of a Self-Inactivating Gammaretroviral Vector for the Gene Therapy of X-linked Chronic Granulomatous Disease
Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity
Safer, Silencing-Resistant Lentiviral Vectors: Optimization of the Ubiquitous Chromatin-Opening Element through Elimination of Aberrant Splicing
Alpharetroviral Vector-mediated Gene Therapy for X-CGD: Functional Correction and Lack of Aberrant Splicing
Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms