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Baojie Wan

University of Illinois Chicago · US
Area of research
Infectious Diseases · Molecular Biology
Research interest
Research focused on Mycobacterium tuberculosis and Tuberculosis, with related work in Drug discovery, Nitro, Oxazole. Notable publications include 'Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2', 'Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase', and 'Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5- a ]pyridine-3-carboxamides as Novel Antitubercular Agents'.
h-index
citations
1,322
works
33
NIH funding
primary concept
email

Recent publications

Nifuroxazide and 4-Hydroxybenzhydrazone Derivatives as New Antiparasitic (Trypanosoma cruzi and Leishmania mexicana) and Anti-Mycobacterium tuberculosis Agents
Pharmaceutics 2025cited by 3position: middledoi
Isolation and Characterization of Anti-Mycobacterial Natural Products from a <i>Petrosia</i> sp. Marine Sponge
Journal of Natural Products 2023cited by 15position: middledoi
Novel Linker Variants of Antileishmanial/Antitubercular 7-Substituted 2-Nitroimidazooxazines Offer Enhanced Solubility
ACS Medicinal Chemistry Letters 2021cited by 14position: middledoi
Chemical Diversity and Antimicrobial Potential of Cultivable Fungi from Deep-Sea Sediments of the Gulf of Mexico
Molecules 2021cited by 12position: middledoi
Quinoline‐Proline, Triazole Hybrids: Design, Synthesis, Antituberculosis, Molecular Docking, and ADMET Studies
Journal of Heterocyclic Chemistry 2021cited by 10position: middledoi
Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal
European Journal of Medicinal Chemistry 2020cited by 21position: middledoi
Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screening
The Journal of Antibiotics 2019cited by 72position: middledoi
Identification of benzothiazinones containing an oxime functional moiety as new anti-tuberculosis agents
European Journal of Medicinal Chemistry 2019cited by 28position: middledoi
Identification of Pyrazolo[1,5-<i>a</i>]pyridine-3-carboxamide Diaryl Derivatives as Drug Resistant Antituberculosis Agents
ACS Medicinal Chemistry Letters 2019cited by 21position: middledoi
Development of (6<i>R</i>)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5<i>H</i>-imidazo[2,1-<i>b</i>][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis
Journal of Medicinal Chemistry 2018cited by 51position: middledoi
Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Antituberculosis Agents
Medicinal Chemistry 2018cited by 26position: middledoi
Anti-Mycobacterium tuberculosis Activity of Esters of Quinoxaline 1,4-Di-N-Oxide
Molecules 2018cited by 18position: middledoi
7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-<i>b</i>][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis
Journal of Medicinal Chemistry 2017cited by 57position: middledoi
Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid
ACS Medicinal Chemistry Letters 2017cited by 45position: middledoi
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases
Bioorganic & Medicinal Chemistry Letters 2017cited by 29position: middledoi
Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity
Bioorganic & Medicinal Chemistry 2017cited by 27position: middledoi
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase
Antimicrobial Agents and Chemotherapy 2016cited by 120position: middledoi
Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-<i>b</i>][1,3]oxazoles for Neglected Tropical Diseases: Structure–Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis
Journal of Medicinal Chemistry 2016cited by 56position: middledoi
Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity
European Journal of Medicinal Chemistry 2016cited by 43position: middledoi
Anti-tuberculosis activity and structure–activity relationships of oxygenated tricyclic carbazole alkaloids and synthetic derivatives
Bioorganic & Medicinal Chemistry 2016cited by 38position: middledoi
Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-<i>a</i>]pyridine-3-carboxamides as Novel Antitubercular Agents
ACS Medicinal Chemistry Letters 2015cited by 96position: middledoi
Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward <i>Mycobacterium tuberculosis</i>
ACS Infectious Diseases 2015cited by 38position: middledoi
Synthesis and Structure–Activity Relationships for Extended Side Chain Analogues of the Antitubercular Drug (6<i>S</i>)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5<i>H</i>-imidazo[2,1-<i>b</i>][1,3]oxazine (PA-824)
Journal of Medicinal Chemistry 2015cited by 38position: middledoi
Discovery of antitubercular 2,4-diphenyl-1H-imidazoles from chemical library repositioning and rational design
European Journal of Medicinal Chemistry 2015cited by 20position: middledoi
Airborne Antituberculosis Activity of <i>Eucalyptus citriodora</i> Essential Oil
Journal of Natural Products 2014cited by 22position: middledoi
Design, synthesis and investigation on the structure–activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents
European Journal of Medicinal Chemistry 2013cited by 66position: middledoi
Enhancing Hit Identification in Mycobacterium tuberculosis Drug Discovery Using Validated Dual-Event Bayesian Models
PLoS ONE 2013cited by 55position: middledoi
Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase
Bioorganic & Medicinal Chemistry 2013cited by 44position: middledoi
Design, synthesis, and evaluation of 4-(substituted)phenyl-2-thioxo-3,4-dihydro-1H-chromino[4,3-d]pyrimidin-5-one and 4-(substituted)phenyl-3,4-dihydro-1H-chromino[4,3-d]pyrimidine-2,5-dione analogs as antitubercular agents
Medicinal Chemistry Research 2013cited by 20position: middledoi
Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2
European Journal of Medicinal Chemistry 2012cited by 131position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Scott G. Franzblau · University of Illinois Chicago30 papers (2012–2025)William A. Denny · University of Otago8 papers (2015–2021)Andrew M. Thompson · University of Otago8 papers (2015–2021)Zhenkun Ma · Ministry of Education of the People's Republic of China7 papers (2015–2021)Louis Maes · University of Antwerp6 papers (2016–2021)Delphine Launay · University of Auckland6 papers (2016–2021) · 5 papers (2017–2021) · 5 papers (2017–2021)Vanessa Yardley · London School of Hygiene & Tropical Medicine5 papers (2016–2021)P. D. T. O’Connor · University of Auckland5 papers (2016–2021)Xiaoyun Lu · Jinan University4 papers (2012–2019) · 4 papers (2017–2021)Yuehong Wang · University of Illinois Chicago4 papers (2015–2017)Adrian Blaser · University of Auckland4 papers (2015–2018)Ke Ding · Shandong University of Technology3 papers (2015–2019)Andrew J. Marshall · University of Auckland3 papers (2017–2020)Tianyu Zhang · South China Agricultural University3 papers (2015–2019)Sang‐Hyun Cho · University of Illinois Chicago3 papers (2013–2019) · 2 papers (2013–2017)Rui Ma · University of Illinois Chicago2 papers (2018–2021)