Area of research
Genetics · Cancer Research
Research interest
Research interests include Genetic Associations and Epidemiology, Cancer-related molecular mechanisms research, Adipokines, Inflammation, and Metabolic Diseases, and Genetic Mapping and Diversity in Plants and Animals.
Dapansutrile preserves pancreatic beta-cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis.
Dapansutrile Regulates Mitochondrial Oxidative Stress and Reduces Hepatic Lipid Accumulation in Diabetic Mice.
Iodine activates NLRP3 inflammasomes in PBMCs of patients with autoimmune thyroiditis and regulates Th1 and Th17 cell differentiation.
Design, synthesis, and biological evaluation of novel potent dual Mer/c-Met inhibitors based on structural optimization
<i>Ramulus Mori</i> (Sangzhi) Alkaloids Improve Pancreatic β-Cell Function Through Gut Microbial and Intra-Islet 2-Methoxyestradiol Biosynthesis.
The trans-ancestral genomic architecture of glycemic traits
Prevalence and reclassification of BRCA1 and BRCA2 variants in a large, unselected Chinese Han breast cancer cohort
Leptin Receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7
Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences
Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits
Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits
Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels
A Low-Frequency Inactivating <i>AKT2</i> Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
Germline determinants of the somatic mutation landscape in 2,642 cancer genomes
Genome-wide associations for birth weight and correlations with adult disease
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Directional dominance on stature and cognition in diverse human populations
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo
Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol
An Embodied, Augmented Reality Coding Platform for Pair Programming
RI: Small: Visual Reasoning and Self-questioning for Explainable Visual Question Answering
RI: Small: A Unified Compositional Model for Explainable Video-based Human Activity Parsing
RI: Small: Modeling and Learning Visual Similarities Under Adverse Visual Conditions
RI: Small: Mining and Learning Visual Contexts for Video Scene Understanding
Collaborative Research: Sino-USA Summer School in Vision, Learning, Pattern Recognition VLPR 2010
RI: Small: Computational Models of Context-awareness and Selective Attention for Persistent Visual Target Tracking
CAREER: Visual Analysis of High-Dimensional Motion: A Distributed/Collaborative Approach
Transductive Learning for Retrieving and Mining Visual Contents
Essential Surfaces and the Topology of 3-Manifolds
U.S.-China Cooperative Research: Fluid Mechanics Investiga-tions of a High Interaction Magnetohydrodynamic Generator