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Matthew G. Holt

VIB-KU Leuven Center for Brain & Disease Research · BE
Area of research
Cellular and Molecular Neuroscience · Cell Biology
Research interest
Research interests include Neuroscience and Neuropharmacology Research, Cellular transport and secretion, Neuroinflammation and Neurodegeneration Mechanisms, and Lipid Membrane Structure and Behavior.
h-index
41
citations
10,951
works
112
NIH funding
primary concept
email

Recent publications

Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Molecular Neurodegeneration 2024cited by 105position: lastdoi
Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice
Nature Communications 2024cited by 47position: middledoi
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain
EMBO Molecular Medicine 2023cited by 32position: middledoi
Corrigendum to “A New Technical Approach for Cross-species Examination of Neuronal Wiring and Adult Neuron-glia Functions” [Neuroscience 508 (2023) 40–51]
Neuroscience 2023cited by 0position: lastdoi
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation
Nature Immunology 2022cited by 209position: middledoi
Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease
Cell Reports 2022cited by 137position: middledoi
Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report
Neurophotonics 2022cited by 44position: middledoi
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model
EMBO Molecular Medicine 2022cited by 42position: lastdoi
Neurotoxicity of four frequently used nanoparticles: a systematic review to reveal the missing data
Archives of Toxicology 2022cited by 31position: middledoi
Reactive astrocyte nomenclature, definitions, and future directions
Nature Neuroscience 2021cited by 2,312position: middledoi
Astrocytes, Noradrenaline, α1-Adrenoreceptors, and Neuromodulation: Evidence and Unanswered Questions
Frontiers in Cellular Neuroscience 2021cited by 67position: lastdoi
Identification of region-specific astrocyte subtypes at single cell resolution
Nature Communications 2020cited by 818position: lastdoi
Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map
Nature Neuroscience 2020cited by 497position: middledoi
Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease
Molecular Neurodegeneration 2020cited by 82position: middledoi
Distinct Mechanisms for Visual and Motor-Related Astrocyte Responses in Mouse Visual Cortex
Current Biology 2019cited by 70position: lastdoi
Production, Purification, and Quality Control for Adeno-associated Virus-based Vectors
Journal of Visualized Experiments 2019cited by 35position: lastdoi
Production, Purification, and Quality Control for Adeno-associated Virus-based Vectors
Journal of Visualized Experiments 2019cited by 10position: lastdoi
Widespread transduction of astrocytes and neurons in the mouse central nervous system after systemic delivery of a self-complementary AAV-PHP.B vector
Gene Therapy 2018cited by 58position: lastdoi
Astrocytes integrate local sensory and brain-wide neuromodulatory signals
bioRxiv (Cold Spring Harbor Laboratory) 2018cited by 5position: lastdoi
Tau association with synaptic vesicles causes presynaptic dysfunction
Nature Communications 2017cited by 449position: middledoi
An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody
Journal of Biological Chemistry 2017cited by 111position: lastdoi
The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A
Cell Reports 2016cited by 60position: middledoi
Drep-2 is a novel synaptic protein important for learning and memory
eLife 2014cited by 54position: middledoi
Small-scale isolation of synaptic vesicles from mammalian brain
Nature Protocols 2013cited by 89position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Catherine Marneffe · KU Leuven5 papers (2019–2024)Melvin Y. Rincón · KU Leuven5 papers (2018–2023)Araks Martirosyan · KU Leuven5 papers (2020–2024)T. Grant Belgard · Orlando Immunology Center4 papers (2017–2024)Bart De Strooper · The Francis Crick Institute4 papers (2017–2022)Filip de Vin · KU Leuven4 papers (2017–2023)Jérôme Wahis · KU Leuven4 papers (2020–2022)Mykhailo Y. Batiuk · KU Leuven4 papers (2017–2023)Marika Marino · KU Leuven3 papers (2019–2022)Zsuzsanna Callaerts‐Vegh · Allen Institute for Brain Science3 papers (2022–2023)Suresh Poovathingal · VIB-KU Leuven Center for Cancer Biology3 papers (2023–2024)Vincent Bonin · Allen Institute for Brain Science3 papers (2018–2022) · 3 papers (2018–2023)Shelly Fripont · KU Leuven3 papers (2018–2019)Sandra Duqué · KU Leuven3 papers (2017–2022)Takashi Saito · UK Dementia Research Institute2 papers (2017–2022)Takaomi C. Saido · Keio University2 papers (2017–2022)Dietmar Rudolf Thal · KU Leuven2 papers (2022–2024) · 2 papers (2018–2019)Francisco Pestana · Allen Institute for Brain Science2 papers (2024–2024)