Area of research
Physiology · Neurology
Research interest
Research interests include Neuroscience, Biology, Disease, Microglia, Hippocampal formation, and Alzheimer's disease.
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice
The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain
Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models
β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer’s disease
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains
Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease
Recent Advances in the Modeling of Alzheimer’s Disease
Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer’s Mice
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia
The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway
Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia.
β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade
YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology
The two faces of synaptic failure in AppNL-G-F knock-in mice
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals
Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model
Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes
SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice
Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice
<scp>APP</scp> mouse models for Alzheimer's disease preclinical studies
Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL−G−F mice before prominent plaque deposition
Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
Istradefylline reduces memory deficits in aging mice with amyloid pathology